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. 2016 Jan 19;113(5):1315–1320. doi: 10.1073/pnas.1518752113

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Fig. S4. — mRNA overexpression of IGF2BP2, PLAG1, and IGF2 in leiomyomas of the HMGA2 subtype. (A) Statistical analysis identified IGF2BP2 as the second-most uniquely expressed gene (FC = 4.4) in leiomyomas of the HMGA2 subtype (blue dots). (B) The proto-oncogene PLAG1 also was among the most uniquely expressed genes (FC = 8.2). Up-regulation of PLAG1 (FC = 5.7) was also seen among the three leiomyomas with genetic HMGA1 alterations (orange dots). Three leiomyomas harbored a genetic PLAG1 alteration (yellow dots) and showed a highly significant up-regulation of PLAG1 (FC = 12.5). (C) PLAG1 is known to regulate the expression of IGF2, and we detected a significant up-regulation (FC = 3.0) of IGF2 in leiomyomas of the HMGA2 subtype. A significant up-regulation of IGF2 was also seen in the leiomyomas with a genetic PLAG1 alteration (FC = 4.3) and in two out of three leiomyomas with a HMGA1 alteration (FC > 2). Of note, leiomyomas of the MED12 subtype also displayed a significant up-regulation of IGF2 (FC = 3.1), and whereas leiomyomas of the FH subtype displayed a significant up-regulation of PLAG1 (FC = 4.8), surprisingly, IGF2 was down-regulated in these lesions (FC = –2.5).