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Isothermal Titration Calorimetry (ITC) data on CaM-Ca++/SH2 interaction without (red) and with (blue) 10-fold excess of compound #1 over SH2 (a), and 25-fold excess of compound #2 over SH2 (b). The “apparent association constant Ka” decreases in the presence of compounds, clearly showing inhibition of interaction by the compounds. The stoichiometry of SH2/CaM-Ca++ complex is 1:1. The compounds do not bind to calmodulin (black dots).
