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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Pharmacol Ther. 2015 Dec 2;158:63–70. doi: 10.1016/j.pharmthera.2015.11.013

Figure 1.

Figure 1

Overview of the PI3K/AKT/mTOR pathway and cellular processes controlled by downstream signaling. RTK, tyrosine-kinase receptor; 4EBP1, eukaryotic initiation factor 4E-binding protein 1; TSC, tuberous sclerosis protein; GS, glycogen synthase. Red circles represent phosphate groups.