. Author manuscript; available in PMC: 2016 Nov 15.

Published in final edited form as: Bioorg Med Chem. 2015 Nov 15;23(22):7226–7233. doi: 10.1016/j.bmc.2015.10.019

Table 2.

Anti-AML activity (AP₅₀/μM)^* of compounds 7i–7l and YTR-107 (1) on the mutant NPM1-expressing OCI-AML3 cell line.

Comp	7i	7j	7k	7l	1
Cell line	AP₅₀	AP₅₀	AP₅₀	AP₅₀	AP₅₀
OCI-AML3	3.31	2.72	1.75	3.3	>20

AP₅₀ represents the concentration of a drug that is required for 50% of the cells to undergo apoptosis in vitro.