Table 4.
Outcomes After Lung Transplant by Recipient HCV Status
| Overall | HCV+ recipient | HCV− recipient | p-value | |
|---|---|---|---|---|
| N | 16,672 | 289 (1.7%) | 16,383 (98.3%) | |
| Post-operative airway dehiscence | 217 (1.3%) | 5 (1.8%) | 212 (1.3%) | 0.433 |
| Post-operative dialysis | 893 (5.4%) | 19 (6.6%) | 874 (5.4%) | 0.441 |
| Post-operative stroke | 369 (2.2%) | 8 (2.8%) | 361 (2.2%) | 0.682 |
| Post-operative infection | ||||
| requiring antibiotics | 4,317 (44%) | 95 (51.6%) | 4,222 (43.9%) | 0.042 |
| Any other post-operative reoperation | 1,798 (18.3%) | 41 (22.3%) | 1,757 (18.2%) | 0.188 |
| Long-term survival | ||||
| 1-year survival, % (95% CI) | 81.2% (80.6–81.8%) | 78.2% (73.5–83.3%) | 81.3% (80.7–81.9%) | |
| 5-year survival, % (95% CI) | 50.6% (49.7–51.4%) | 42.1% (36.0–49.1%) | 50.7% (49.8–51.6%) | |
| Median survival, years (95% CI) | 5.1 (5.0–5.3) | 3.8 (2.9–4.9) | 5.1 (5.0–5.3) | 0.005 |
| Cause of death | 0.368a | |||
| Graft failure | 1,590 (20.5%) | 25 (16.6%) | 1,565 (20.6%) | 0.267 |
| Pulmonary | 1,489 (19.2%) | 22 (14.6%) | 1,467 (19.3%) | 0.176 |
| Infection | 1,938 (25%) | 47 (31.1%) | 1,891 (24.9%) | 0.096 |
| Infection—hepatitis | 4 (0.1%) | 0 (0%) | 4 (0.1%) | 0.999 |
| Liver failure | 53 (0.7%) | 1 (0.7%) | 52 (0.7%) | 0.999 |
| Cardio- or cerebrovascular | 733 (9.5%) | 13 (8.6%) | 720 (9.5%) | 0.829 |
| Malignancy | 626 (8.1%) | 18 (11.9%) | 608 (8%) | 0.109 |
| Multiple-organ failure | 455 (5.9%) | 7 (4.6%) | 448 (5.9%) | 0.635 |
| Other | 868 (11.2%) | 18 (11.9%) | 850 (11.2%) | 0.875 |
p-values represent results of Pearson’s chi-square test or Fisher’s exact test as appropriate, with the exception of median survival, which was compared using the log-rank test. Results in parentheses for long-term survival represent 95% confidence interval (CI).
a
p-values for cause of death represent the overall chi-square test, while the individual p-values compare each cause as a binary variable. The type of infectious hepatitis was not defined.