Table 3.
Association of epithelial plasticity biomarker expression with PSA recurrence.
| Biomarker (number evaluable) | Univariate Hazard Ratio for PSA recurrence, 95% CI | 5-year PSA recurrence rate(%) and 95% CI | 10-year PSA recurrence rate (%)and 95% CI |
|---|---|---|---|
|
| |||
| Median Ki-67 (n=164) | |||
| Ki67 tertile 1 (n=57) | 0.84 (0.50, 1.40) | 60% (45%, 72%) | 46% (30%, 60%) |
| Ki-67 tertile 2 (n=52) | 0.48 (0.28, 0.83) | 71% (58%, 81%) | 64% (50%, 75%) |
| Ki-67 tertile 3 (n=55) | REF | 44% (31%, 57%) | 38% (25%, 52%) |
| SNAIL (maximum), n=188 | 47% (35%, 61%) | ||
| Absent SNAIL (n=58) | 1.47 (0.84, 2.58) | 45% (34%, 58%) | 54% (41%, 69%) |
| SNAIL 1+ (n=74) | 1.39 (0.82, 2.37) | 31% (21%, 45%) | 52% (40%, 64%) |
| SNAIL 2–3+ (n=56) | REF | 42% (29%, 59%) | |
| ZEB1 (maximum), n=189 | |||
| Absent ZEB1 (n=160) | 0.91 (0.51, 1.65) | 41% (34%, 49%) | 49% (41%, 57%) |
| ZEB1 1–2+ (n=29) | REF | 48% (30%, 69%) | 61% (37%, 86%) |
| Vimentin (maximum), n=203 | |||
| Absent vimentin (n=145) | 1.40 (0.86, 1.29) | 43% (35%, 52%) | 51% (43%, 61%) |
| Vimentin 1–2+ (n=58) | REF | 32% (22%, 47%) | 38% (27%, 53%) |
| E-cadherin (minimum), n=205 | |||
| Absent-low E-cadherin (n=29) | 0.62 (0.32, 1.19) | 24% (12%, 44%) | 36% (21%, 57%) |
| E-cadherin 2+ (n=176) | REF | 43% (36%, 51%) | 50% (42%, 58%) |
| TWIST (maximum), n=148 | |||
| Absent-low TWIST (n=10) | 1.56 (0.67, 3.61) | 50% (25%, 82%) | 60% (33%, 88%) |
| TWIST 2–3+ (n=138) | REF | 40% (32%, 49%) | 47% (38%, 56%) |