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. Author manuscript; available in PMC: 2017 Feb 28.
Published in final edited form as: J Control Release. 2015 Dec 28;224:69–76. doi: 10.1016/j.jconrel.2015.12.044

Table 1.

PK parameters of ziconotide in CSF following intranasal and intravenous administration.

CSF Intranasal ziconotide Intranasal ziconotide with Chitosan Intravenous ziconotide
AUC0-6 (min.μg/mL) 1.57 ± 0.44 10.73 ± 2.92 4.98 ± 0.98
Cmax (ng/mL) 33.55 ± 7.39 244.34 ± 48.6 37.78 ± 6.8
Tmax (min) 15 15 120
KE (h−1) 0.54 ± 0.08 0.69 ± 0.17 0.43 ± 0.10