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. Author manuscript; available in PMC: 2016 May 18.
Published in final edited form as: Int J Obes (Lond). 2015 Sep 16;40(2):266–274. doi: 10.1038/ijo.2015.181

Figure 2. Leptin regulates adiponectin expression in differentiated human white preadipocytes (HWP).

Figure 2

In-vitro treatment of differentiated HWP with increasing concentrations of leptin increases adiponectin mRNA (A) and protein (B) in a dose-dependent manner. However, leptin does not increase adiponectin secretion (C). Treatment of differentiated HWP with leptin antagonist decreases adiponectin mRNA (D), protein (E), and secretion (F). Data presented as mean ± SEM (n=4). *P ≤ 0.05 compared with control as determined by Wilcoxon rank-sum test. Total adiponectin: grey bars; high molecular weight adiponectin: black bars.