Skip to main content
. Author manuscript; available in PMC: 2016 May 18.
Published in final edited form as: Int J Obes (Lond). 2015 Sep 16;40(2):266–274. doi: 10.1038/ijo.2015.181

Figure 5. Increased caveolin-1 expression contributes to impaired leptin-dependent activation of cellular signaling pathways in adipose tissue from obese (Ob, black bars) subjects.

Figure 5

The expression of leptin receptor (Ob-R) (A), and SOCS-3 (B) was not different in adipose tissue from obese participants, but caveolin-1 protein expression (C) was increased significantly. Furthermore, caveolin-1 overexpression impaired leptin-dependent increases in adiponectin mRNA in cultured differentiated HWP (D, checkered bars). Data presented as mean ± SEM. *P ≤ 0.05 compared to normal weight subjects (N) / control (Leptin: 0 ng/ml) as determined by Wilcoxon rank-sum test.