Table 1.
Correlation between PIM1 expression and the clinicopathological characteristics.
| Variables | Number of Patients | PIM1 expression (%) | χ2 | *P-value | |
|---|---|---|---|---|---|
| Low/none | High | ||||
| Gender | |||||
| Female | 72 | 33(45.8) | 39(54.2) | 5.508 | 0.019 |
| Male | 122 | 77(63.1) | 45(36.9) | ||
| Age (years) | |||||
| < 60 | 101 | 53(52.5) | 48(47.5) | 1.532 | 0.216 |
| ≥ 60 | 93 | 57(61.3) | 36(38.7) | ||
| Smoking index | |||||
| < 400 | 95 | 55 (54.7) | 43(45.3) | 0.293 | 0.589 |
| ≥ 400 | 99 | 58(58.6) | 41(41.4) | ||
| Clinical Stage | |||||
| I | 84 | 48(57.1) | 36(42.9) | 3.206 | 0.361 |
| II | 43 | 28(65.1) | 15(34.9) | ||
| IIIa | 54 | 29(53.7) | 25(46.3) | ||
| IIIb | 13 | 5(38.5) | 8(61.5) | ||
| Tumor size | |||||
| ≤ 3cm | 92 | 45(48.9) | 47(51.1) | 4.323 | 0.038 |
| > 3cm | 102 | 65(63.7) | 37(36.3) | ||
| Regional LN metastasis | |||||
| No | 107 | 68(63.6) | 39(36.4) | 4.561 | 0.033 |
| Yes | 87 | 42(48.3) | 45(51.7) | ||
| Distant metastasis | |||||
| No | 180 | 105(58.3) | 75(41.7) | 2.707 | 0.100 |
| Yes | 14 | 5(35.7) | 9(64.3) | ||
| Histology | |||||
| AD | 101 | 47(46.5) | 54(53.5) | 8.870 | 0.003 |
| SCC | 93 | 63(67.7) | 30(32.3) | ||
| Pathologic differentiation | |||||
| Well | 64 | 31(53.1) | 33(46.9) | 2.656 | 0.103 |
| Poor | 130 | 79(60.8) | 51(39.2) | ||
| p-STAT3 expression | |||||
| Low/ none | 99 | 63(63.6) | 36(36.4) | 3.961 | 0.047 |
| High | 95 | 47(49.5) | 48(50.5) | ||
| c-MYC expression | |||||
| Low/ none | 93 | 51(54.8) | 42(45.2) | 0.252 | 0.615 |
| High | 101 | 59(58.4) | 42(41.6) | ||
| Total | 194 | 110(56.7) | 84(43.3) | ||
LN: lymph node. SCC: squamous cell carcinoma. AD: adenocarcinoma. *P values < 0.05 in bold.