Table 3.

Predictive and prognostic values of variables by univariate analysis.

Variables	DFS			OS
	3-year DFS rate (%)	χ2	*P value	5-year survival rate (%)	χ2	*P value
All patients (n=194)
Gender
Male	58.9	0.412	0.521	45.7	1.316	0.251
Female	51.8			51.6
Age (years)
≥ 60	54.1	2.142	0.143	41.5	1.995	0.158
< 60	58.3			53.6
Smoking index
≥ 400	58.7	0.398	0.528	45.4	1.147	0.284
< 400	53.6			50.3
Clinical Stage
IIIa-IIIb	40.2	22.116	< 0.001	26.6	22.853	< 0.001
Ia-IIb	64.7			59
Tumor size
> 3cm	55	1.259	0.262	42.2	2.710	0.100
≤ 3cm	57.6			54
Regional LN metastasis
Yes	40	23.226	< 0.001	31.3	20.101	< 0.001
No	69.5			61.4
Histology
AD	50.3	3.157	0.076	50.7	1.669	0.196
SCC	63.2			44.8
Pathologic differentiation
Poor	50.3	2.318	0.128	41.5	5.870	0.015
Well	65.2			59.8
PIM1 expression
High	39.7	8.245	0.004	37.5	8.370	0.004
Low/ none	67.4			55.7
p-STAT3 expression
High	49.9	2.424	0.12	43.2	1.153	0.283
Low/ none	62.6			52.2
c-MYC expression
High	54	0.033	0.856	52.4	0.423	0.515
Low/ none	57.9			44.8
PIM1 and pSTAT3 expression
Both high	31.6	9.711	0.008	35.7	6.676	0.036
Either high	59.3			41.9
Both low/ none	69.1			59.6
Patients in stage I-II (n=127)
PIM1 expression
High	42.1	9.956	0.002	51.4	4.069	0.044
Low/ none	76			64.6
p-STAT3 expression
High	60	1.205	0.272	53.5	1.349	0.246
Low/ none	68.5			64.1
c-MYC expression
High	64	0.185	0.667	59.2	0.001	0.993
Low/ none	62.6			58.8
Patients in stage III (n=67)
PIM1 expression
High	30.9	0.151	0.697	18.2	1.089	0.297
Low/ none	47.6			35.6
p-STAT3 expression
High	34.7	0.04	0.841	26.2	0.114	0.736
Low/ none	48.8			26.9
c-MYC expression
High	36.4	0.127	0.721	16.9	1.111	0.292
Low/ none	41.9			34.4

DFS: disease-free survival. OS: overall survival. SCC: squamous cell carcinoma. AD: adenocarcinoma. *P values < 0.05 in bold.