Table 2.
Parameters from two-compartment FITC-sinistrin pharmacokinetics
| INV | DDNx | P | |
|---|---|---|---|
| GFR, ml/min | 11.2 ± 0.5 | 10.6 ± 2.0 | 0.78 |
| ECFV, ml | 604.3 ± 28.8 | 549.7 ± 59.8 | 0.44 |
| Vhigh-perfusion, ml | 242.7 ± 11.6 | 261.1 ± 32.8 | 0.62 |
| Vlow-perfusion, ml | 361.7 ± 20.8 | 288.6 ± 37.8 | 0.31 |
| kelim, min−1 | 0.047 ± 0.004 | 0.04 ± 0.002 | 0.13 |
| khigh→low, min−1 | 0.083 ± 0.007 | 0.073 ± 0.010 | 0.41 |
| klow→high, min−1 | 0.057 ± 0.005 | 0.068 ± 0.012 | 0.43 |
Data are presented as means ± SE, n = 6. Vhigh-perfusion and Vlow-perfusion, volumes of high- and low-perfusion compartments, respectively; k, first-order kinetic constant. Renal denervation did not significantly affect any physiological parameters derived from two-compartment modeling of the fluorescein isothiocyanate (FITC)-sinistrin plasma decay, including glomerular filtration rate (GFR) and extracellular fluid volume (ECFV).