Fig. 3.

Representative Doppler profiles for aortic valve (AoV) outflow and mitral valve inflow velocity. A: at the 6- to 14-mo age group, Doppler interrogation demonstrates normal left ventricular outflow (AoV) tract without regurgitation (a), mild aortic regurgitation (b), and severe aortic regurgitation (c). B: mitral valve outflow (a) and normal mitral valve outflow (b). Significant outflow (regurgitation) patterns are observed (arrows) in HT mice with chamber dilatation. C: quantification of mitral valve outflow velocity (regurgitation). Outflow velocity was significantly increased in 6- to 14-mo-old Marfan HT mice with cardiac dilatation. Values are means ± SE; n = 5–8 animals per group. *P < 0.05, WT vs. HT mice.