Table 2.
Hemodynamic indexes of WT and HT groups in young and older adult mice
| 2–4 m, Young |
6–14 m, Older adult |
||||
|---|---|---|---|---|---|
| Pressure-Volume Parameters | WT | HT | WT | HT constricted | HT dilated |
| n | 7 | 6 | 12 | 5 | 7 |
| HR, beats/min | 561 ± 35 | 531 ± 29 | 547 ± 23 | 445 ± 31 | 463 ± 55 |
| ESV, μl | 21.3 ± 2.1 | 18.0 ± 2.1 | 19.7 ± 2.0 | 16.0 ± 1.7 | 38.7 ± 1.4**## |
| EDV, μl | 34.1 ± 1.9 | 30.6 ± 2.8 | 36.6 ± 1.1 | 26.2 ± 1.5* | 46.3 ± 1.7**## |
| SV, μl | 14.4 ± 1.7 | 11.6 ± 2.3 | 13.9 ± 1.4 | 5.4 ± 0.8** | 7.2 ± 0.9* |
| Ea, mmHg/μl | 6.1 ± 0.7 | 7.1 ± 0.9 | 7.2 ± 0.5 | 10.1 ± 1.3** | 4.3 ± 0.3*## |
| +dP/dt, mmHg/s | 8,566 ± 348 | 5,122 ± 313* | 8,507 ± 849 | 4,998 ± 606* | 3,647 ± 525** |
| −dP/dt, mmHg/s | 6,713 ± 654 | 4,713 ± 611* | 6,744 ± 807 | 3,928 ± 387* | 2,844 ± 434** |
| τW, ms | 7.9 ± 0.2 | 13.2 ± 1.1* | 7.5 ± 0.6 | 13.9 ± 1.8* | 9.5 ± 1.6 |
| PRSW, mmHg·μl−1·μl−1 | 69 ± 6 | 45 ± 4* | 67 ± 7 | 43 ± 5* | 36 ± 4** |
| Ees, mmHg/μl | 8.9 ± 1.2 | 6.9 ± 0.7 | 8.5 ± 1.1 | 3.1 ± 0.6** | 2.7 ± 0.5** |
| Eed, 10−3 × mmHg/μl | 0.22 ± 0.02 | 0.39 ± 0.03* | 0.23 ± 0.03 | 0.44 ± 0.05** | 0.42 ± 0.04** |
| Ea/Ees | 0.87 ± 0.08 | 0.94 ± 0.01 | 0.68 ± 0.05 | 2.7 ± 0.06** | 1.6 ± 0.07*## |
Values are means ± SE; n, no. of mice. HR, heart rate; ESL, end-systolic volume; EDV, end-diastolic volume; SV, stroke volume; Ea, aortic elastance; +dP/dt, peak rate of pressure rise; −dP/dt, peak of pressure decline, τW, time rate of relaxation (Weiss); PRSW, preload recruitable stroke work; Ees, end-systolic elastance; Eed, end-diastolic elastance; Ea/Ees, arterioventricular coupling.
*
P < 0.05 and
**
P < 0 0.01: WT vs. HT (in respective age groups).
##
P < 0.01: HT constricted vs. dilated (Bonferroni post hoc comparison).