Table 1.
Arterial hemoglobin concentration and pH at different ranges of arterial O2 saturation
| Arterial O2 Saturation |
||||
|---|---|---|---|---|
| Treatment | 90–100% | 80–90% | 70–80% | 50–70% |
| Hemoglobin, g/l | ||||
| Vehicle | 106 ± 5 | 105 ± 4 | 106 ± 8 | 108 ± 6 |
| MS-PPOH | 104 ± 4 | 106 ± 7 | 106 ± 12 | 109 ± 7 |
| 14,15-EEZE | 104 ± 4 | 102 ± 6 | 104 ± 10 | 115 ± 10 |
| MPEP + LY367385 | 108 ± 6 | 109 ± 7 | 108 ± 5 | 108 ± 5 |
| SCH58261 | 113 ± 3 | 113 ± 5 | 110 ± 6 | 111 ± 5 |
| MRS1754 | 103 ± 4 | 104 ± 4 | 101 ± 5 | 104 ± 6 |
| Glibenclamide | 106 ± 3 | 104 ± 4 | 105 ± 5 | 105 ± 6 |
| HET0016 | 107 ± 8 | 112 ± 5 | 111 ± 4 | 106 ± 4 |
| pH | ||||
| Vehicle | 7.38 ± 0.01 | 7.37 ± 0.01 | 7.38 ± 0.02 | 7.39 ± 0.02 |
| MS-PPOH | 7.36 ± 0.01 | 7.37 ± 0.01 | 7.36 ± 0.02 | 7.31 ± 0.04* |
| 14,15-EEZE | 7.37 ± 0.02 | 7.37 ± 0.01 | 7.35 ± 0.03 | 7.34 ± 0.03 |
| MPEP + LY367385 | 7.37 ± 0.01 | 7.37 ± 0.01 | 7.36 ± 0.02 | 7.34 ± 0.02* |
| SCH58261 | 7.37 ± 0.01 | 7.37 ± 0.01 | 7.36 ± 0.02 | 7.35 ± 0.03 |
| MRS1754 | 7.37 ± 0.01 | 7.36 ± 0.01 | 7.35 ± 0.02 | 7.34 ± 0.03 |
| Glibenclamide | 7.37 ± 0.01 | 7.37 ± 0.01 | 7.34 ± 0.02 | 7.35 ± 0.02 |
| HET0016 | 7.37 ± 0.01 | 7.37 ± 0.01 | 7.35 ± 0.01 | 7.34 ± 0.01* |
Values are means ± 95% confidence intervals.
MS-PPOH, N-methylsulfonyl-6-(2-propargyloxyphenyl)hexanamide; 14,15-EEZE, 14,15-epoxyeicosa-5(Z)-enoic acid; LY367385, (S)-(+)-α-amino-4-carboxy-2-methylbenzeneacetic acid; MPEP, 2-methyl-6-(phenylethynyl)pyridine.
*
P < 0.05 from vehicle group by Dunnett's test.