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. 2016 Feb 4;61(3):434–448. doi: 10.1016/j.molcel.2015.12.017

Figure 7.

Figure 7

A Model Showing IR-Induced Phosphorylation of Abraxas Promotes Dimerization of BRCA1 at Sites of DNA Damage for BRCA1 Accumulation and Cellular Response to IR

In the absence of IR, two BRCA1 bound to BRCA1-A complex do not form stable dimer. Extra phosphorylation at Abraxas S404 induced by IR leads to the stable dimerization of BRCA1 at the DNA damaged site. The BRCT-Abraxas interaction is indicated in a dashed circle for the “pair-hugging” interaction model. The BRCT domains are represented by gray circles and Abraxas phosphopeptides by pink lines. The line with double arrows indicates interaction for dimerization (P indicates the phosphorylation).