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Schemata showing the proposed role of the Cav-1 in the regulation of ATG12-ATG5 system during the autophagic process. Under basal conditions, Cav-1 forms complexes with ATG5, ATG12, and the ATG12-ATG5 conjugate. Stimulation of lung epithelial cells with starvation or other stresses, or knockdown of Cav-1, results in the rapid dissociation of these complexes, and subsequently the ATG12-ATG5 conjugate triggers the autophagic process.
