Fig. 3.

Histology (HE staining) of radiation-induced nephropathy in mice. Representative histological images (×20 magnification) of kidneys from untreated controls (final score 0) and progressively severe kidney damage (final scores 1–5) from mice injected with different activities of ¹⁶¹Tb-folate (▲ = localized tubular collapse; v = viable tubules; Δ = enlarged glomeruli with reduced numbers of capillaries; → = glomerulosclerosis). In the insets, cross sections of the kidneys are presented (×2 magnification) indicating gradual thinning of the cortex (↔) with increasing scores