1 |
Glomeruli: mild deposition of PTAH-positive eosinophilic material (fibrin) and reduced number of capillaries in a few glomeruli. |
Tubules: <10 % of cortical tubules collapsed or degenerated. |
Interstitium: few small mononuclear cell infiltrates and/or minimal fibrosis in the cortex. |
2 |
Glomeruli: mild/moderate fibrin deposition and reduced number of capillaries in numerous glomeruli. |
Tubules: 10–25 % of cortical tubules collapsed or degenerated. |
Interstitium: multifocal small mononuclear cell infiltrates and/or mild fibrosis in the cortex. |
3 |
Glomeruli: marked fibrin deposition and reduced number of capillaries in numerous glomeruli. |
Tubules: 25–50 % of cortical tubules collapsed or degenerated. |
Interstitium: multifocal larger mononuclear cell infiltrates and/or moderate fibrosis in the cortex. |
4 |
Glomeruli: marked fibrin deposition and reduced number of capillaries in numerous glomeruli; glomerulosclerosis in a few to several glomeruli. |
Tubules: 50–75 % of cortical tubules collapsed or degenerated; numerous dilated tubules. |
Interstitium: multifocal larger mononuclear cell infiltrates and/or moderate fibrosis in the cortex and medulla; mild/moderate parenchymal collapse. |
5 |
Glomeruli: majority of glomeruli sclerotic. |
Tubules: >75 % of cortical tubules collapsed or degenerated; numerous dilated tubules. |
Interstitium: severe parenchymal collapse, affecting cortex and medulla. |