Table 6.
Control | 161Tb-folate | 177Lu-folate | |||||
---|---|---|---|---|---|---|---|
Group Aa(n = 9) | Group B: 10 MBq | Group C: 20 MBq | Group D: 30 MBq | Group E: 10 MBq | Group F: 20 MBq | Group G:30 MBq | |
(n = 5)a | (n = 5)a | (n = 2)b | (n = 5)a | (n = 4)a | (n = 5)b | ||
Glomeruli | 0 | 1.1 | 3.4 | 5.0 | 2.0 | 3.8 | 5.0 |
Tubules | 0 | 0.9 | 2.4 | 4.5 | 1.5 | 3.3 | 4.2 |
Interstitium | 0 | 0.4 | 1.8 | 4.0 | 0.4 | 3.3 | 4.6 |
Cumulative score | 0 | 2.4 | 7.6 | 13.5 | 3.9 | 10.4 | 13.8 |
Final score | 0 | 1 | 3 | 4 | 2 | 3 | 4 |
The sum of the partial scores determined the cumulative scores, which were then converted to the final score as a measure for the different degrees of renal injury
aMice euthanized in Week 34
bMice euthanized between Weeks 15 and 26