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. 2016 Feb 9;6:11. doi: 10.1186/s13550-016-0170-2

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© Koga et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Pharmacokinetics of non-radiolabelled compounds in the rat brain. a–f The concentrations of TASP0410457 (a), TASP0434988 (b), TASP0390136 (c), TASP0390174 (d), TASP0410426 (e), and TASP0410427 (f) in the forebrain (closed circles) and cerebellum (open circles) were determined by ex vivo LC-MS/MS after the intravenous administration of 10 μg/kg of the compound in rats. The absence of symbols at 60 or 120 min in the plots indicates that the concentration measures were below the lower limit of quantification. Data are mean ± S.E.M (n = 3)