Figure 1.

Identification of highly immunogenic regions by MHC-binding predictions. The median value of the consensus percentile rank scores of binding to supertype-defining HLA II alleles was obtained from predictions by the IEDB webservice, for each 15-mer peptides.²⁶ Since the smaller consensus percentile rank a peptide has, the better binding is expected, percentile rank values were converted to binding scores by subtraction of the value from 100. The 100 minus median rank values are shown for the top scoring 20% (15 peptides) as a function of starting residues.