Table 1.
Incidence of multigland disease in recent cohorts of patients undergoing bilateral neck exploration
| Reference (year) | Period, centre, operative strategy | Total number of patients | Double adenomas | Multigland hyperplasia |
|---|---|---|---|---|
| Alhefdhi et al. [11] | 2001–2013, University of Wisconsin, USA | 1402 | 124 (9 %) | 181 MGD (13 %) |
| Vandenbulcke et al. [12] | 1993–2010, University Hospitals Leuven, Belgium, BNE | 698 | 46 (6.6 %) | 17 (2.4 %) |
| Mazeh et al. [13] | 2001–2010, University of Wisconsin, USA, BNE | 1235 | 100 (8 %) | 135 (11 %) |
| Schneider et al. [14] | University of Wisconsin, USA | 1049 overt PHPT | 148 (14.1 %) | |
| 388 mild PHPT | 133 (34.3 %) | |||
| Hughes et al. [15] | Ann Arbor, USA, focused parathyroidectomy with MGD discovered intraoperatively | 1855 | 207 (11 %) | |
| Cayo et al. [16] | 2000–2008, University of Wisconsin, USA | 755 | 163 (21.5 %) | |
| Szabo et al. [17] | Uppsala University Hospital, Sweden, BNE | 659 | 77 (11.7 %) | 53 (8.0 %) |
| Attie et al. [18] | Long Island Jewish Medical Centre, USA, BNE | 865 | 33 (3.8 %) | 46 (5.3 %) |
MGD multiglandular disease, PHPT primary hyperparsathyroidism, BNE bilateral neck exploration