Table 7.
Summary of the indications for genetic screening
| Clinical manifestation of MEN-1 syndrome and indications for genetic screening | ||
|---|---|---|
| Major lesion (prevalence) | Minor lesions | Indications for genetic screening |
| Hyperparathyroidism (90–97 %) | Adrenal adenomas | Index case |
| Pituitary adenoma (33 %) | Facials angiofibromas | Clinically defined MEN-1 |
| Tumours of endocrine pancreas (30–80 %) | Lipomas | (2 major lesions; 3 major and minor lesions) |
| Neuroendocrine carcinoids | Clinically suspicious or atypical MEN-1 | |
| Thyroid neoplasms | ||
| Phaeochromocytomas | ||
| Malignant melanomas | Member of a MEN-1 family | |
| Testicular teratomas | All first degree relatives: a relative who shows signs or symptoms of MEN-1 | |
Modified from ref. [76]