Table 1.
Characteristics of ARDS patients by CMV reactivation status
| Reactivation (n = 74) | Non-reactivation (n = 197) | p value | |
|---|---|---|---|
| Patient characteristics | |||
| Age (years) | 64 (56–74) | 64 (54–72) | 0.50 |
| Male gender | 44 (59) | 120 (61) | 0.83 |
| Non-European descent | 13 (18) | 27 (14) | 0.42 |
| Prior ICU admission during hospital stay | 16 (22) | 24 (12) | 0.05 |
| Surgical reason for admission | 22 (30) | 73 (37) | 0.26 |
| COPD | 13 (18) | 30 (15) | 0.64 |
| Congestive heart failure | 2 (3) | 9 (5) | 0.49 |
| Diabetes mellitus | 14 (19) | 26 (13) | 0.24 |
| Cancer | 9 (12) | 28 (14) | 0.66 |
| Renal insufficiency | 12 (16) | 11 (6) | <0.01 |
| Markers of disease severity | |||
| APACHE IV score | 91 (71–113) | 76 (62–99) | <0.01 |
| Septic shock | 42 (57) | 81 (41) | 0.02 |
| Plasma lactate | 3.6 (1.9–6.5) | 3.5 (1.9–5.8) | 0.47 |
| C-reactive protein | 244 (129–310) | 241 (151–309) | 0.99 |
| ≥3 quadrant consolidation | 49 (66) | 121 (61) | 0.47 |
| Tidal volume (mL/kg body weight) | 6.5 (5.5–7.6) | 6.5 (5.6–7.8) | 0.72 |
| PEEP setting (cmH2O) | 12 (10–15) | 10 (8–15) | 0.16 |
| P/F | 107 (77–150) | 106 (82–149) | 0.41 |
| Pulmonary compliance (mL/cmH2O) | 35 (24–47) | 39 (27–49) | 0.15 |
| Therapeutic interventions | |||
| High dose corticosteroid therapy | 48 (65) | 101 (51) | 0.05 |
| Transfusion of blood products | 15 (20) | 18 (9) | 0.18 |
Markers of disease severity represent the worst values observed during the first 4 days in ICU, except for tidal volume, which represents the mean value. Therapeutic interventions relate to the first 4 days in ICU only. High dose corticosteroid was defined as a daily dose of ≥250 mg hydrocortisone or equivalent
Data are presented as medians (interquartile range) or absolute numbers (%). p values were calculated by nonparametric tests and Chi square tests, respectively
APACHE Acute Physiology and Chronic Health Evaluation, ARDS acute respiratory distress syndrome, COPD chronic obstructive pulmonary disease, ICU intensive care unit, PEEP positive end expiratory pressure, P/F partial pressure of oxygen in arterial blood to fraction of inspired oxygen ratio