Table 1.
Baseline characteristics of the 91 ADPKD patients included in the present study
| All | Stratified according to eGFR (ml/min*1.73m2) | |||
|---|---|---|---|---|
| >70 | ≤70 | p-value | ||
| Number of participants | 91 | 57 | 34 | |
| Age (y) | 39.8 ± 11.4 | 34.9 ± 8.5 | 48.0 ± 11.2 | <0.001 |
| Male (%) | 58.2 % | 54.4 % | 64.7 % | 0.3 |
| Diastolic BP (mm Hg) | 79.9 ± 9.6 | 79.9 ± 9.7 | 79.9 ± 9.5 | 0.9 |
| Systolic BP (mm Hg) | 129.2 ± 11.9 | 129.4 ± 12.0 | 128.9 ± 12.0 | 0.8 |
| Antihypertensive medication (%) | 79.1 % | 70.2 % | 94.1 % | 0.007 |
| Plasma Osmolality (mOsm/kg) | 288 ± 6.7 | 286.5 ± 6.5 | 290.8 ± 6.2 | 0.004 |
| Serum Copeptin (pmol/l) | 6.5 (3.0-14.7) | 4.4 (2.7 – 8.8) | 13.2 (8.0 – 18.1) | <0.001 |
| eGFR (ml/min*1.73m2) | 79.2 ± 28.8 | 98.1 ± 15.3 | 47.5 ± 14.7 | <0.001 |
| Renal blood flow (MRI) (ml/min*1.73m2) | 814 ± 302 | 973.6 ± 243 | 545 ± 174 | <0.001 |
| Renal blood flow (hippuran) (ml/min*1.73m2) | 440 ± 157 | 533 ± 109 | 285 ± 86.7 | <0.001 |
| Total kidney volume (mL/m) | 852 (251 – 1272) | 729 (483 – 1083) | 1167 (748 – 1434) | 0.003 |
| 24h urinary volume (mL) | 2255 ± 767 | 2173 ± 842 | 2392 ± 613 | 0.2 |
| 24h urinary sodium excretion (mmol) | 173 ± 71 | 184 ± 74 | 157 ± 65 | 0.1 |
| 24h urinary albumin excretion (mg) | 36.3 (14.2 - 117.8) | 36.3 (14.8 – 88.0) | 42.4 (13.3 – 178.4) | 0.4 |
Note: Unless otherwise indicated, values for categorical variables are given as percentages; values for continuous variables are given as the mean ± standard deviation (if parametric) or median [interquartile range] if nonparametric. P-values indicate differences between >70 ml/min*1.73m2 and ≤70 ml/min*1.73m2.
P-values are calculated by t-tests when normally distributed and by Mann-Whitney U tests when non-normally distributed. Abbreviations: ADPKD, autosomal dominant polycystic kidney disease; BP, blood pressure; eGFR, estimated glomerular filtration rate