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The S. griseus A-factor regulon. Similar to Gram-negative bacteria, at threshold concentrations the diffusible A-factor (a γ-butyrolactone) binds the intracellular receptor ArpA and activates expression of the transcriptional activator AdpA which in-turn regulates multiple phenotypes either indirectly via a multi-step cascade, such as the development of aerial hyphae and sporulation, or directly, such as the production of secondary metabolites like streptomycin.
