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. 2016 Feb 10;36(6):1871–1878. doi: 10.1523/JNEUROSCI.3131-15.2016

Figure 3.

Figure 3.

Inverse relationship between aerobic glycolysis enzyme expression and memory performance in APP/PS1 mice. A, Memory performance in the MWM correlated with the expression of aerobic glycolysis enzymes in the frontal cortex of both control mice (n = 6) and APP/PS1 mice (n = 6) at 12 months of age. Higher expression of enzymes involved in lactate production, including lactate dehydrogenase A (LDHA), pyruvate kinase M2/M1 ratio (PKM2/PKM1) and phospho-pyruvate dehydrogenase versus total pyruvate dehydrogenase (PDK-p/PDH) correlated with better memory performance for control mice, but not for APP/PS1 mice. Higher expression of lactate dehydrogenase B (LDHB), an enzyme that consumes lactate, correlated with decreased memory performance for control mice, but an increase in memory performance for APP/PS1 mice. B, Levels of Aβ(1–40)/Aβ(1–42) in both soluble (left) and insoluble (right) cortical extracts from APP/PS1 mice at 12 months of age were correlated with LDHA and LDHB expression. An inverse trend between Aβ1–42 levels and LDHA was detected. Increased levels of Aβ(1–42) weakly correlated with elevated expression of LDHB. *p < 0.05, **p < 0.01.