Figure 3.

Ectopic mice have no deficit in auditory thalamic sensitivity to rapid click trains. a, Example responses to click trains from a neuron recorded in ventral MGB of an ectopic mouse. Insets, Superimposed rasters and PSTHs, with click stimuli (pink) indicated below. Synchronization of firing to each click train was quantified with the Rayleigh score (R) of vector strength. The minimum ICI for synchronization (arrow) was defined as the smallest ICI for which the vector strength was significant at the 0.001 level (R > 13.8). Closed circles represent significant vector strength. Open circles represent not significant. b, No differences between ectopic and nonectopic mice in distributions of minimum ICI for synchronization to click trains, for all recorded MGB neurons. Conventions as in Figure 1d. c–e, Same analysis and results for neurons recorded in ventral MGB (c), dorsal MGB (d), and medial MGB (e). f, No differences between ectopic and nonectopic mice in thalamic responses to 6.25 ms ICI (160 clicks/s) click trains, for all MGB recordings with statistically significant synchronized firing to those trains. Conventions as in Figure 2. Left to right, Peak firing rate for response to first or second click in rapid click trains; probability of firing to first or second click. b–f, Results of Wilcoxon rank-sum tests for differences in medians are indicated; N.S., not significant (see text). Kolmogorov–Smirnov tests for differences in distributions produced similar results.