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. 2016 Feb 10;36(6):2057–2067. doi: 10.1523/JNEUROSCI.3318-15.2016

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Copyright © 2016 the authors 0270-6474/16/362058-11$15.00/0

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Figure 5. — The wake-promoting effect of cholinergic stimulation is strongly attenuated by simultaneous reverse microdialysis of cholinergic receptor antagonists into the BF. Reverse microdialysis of atropine (atr, 50 μm), or a mixture of atropine (50 μm) and mecamylamine (mec, 1 mm) into the BF during optogenetic stimulation of cholinergic neurons abolishes the effect on the following: a, wakefulness; b, probability of NREM sleep to wakefulness transitions; c, NREM sleep to wakefulness latency; and d, transitions from NREM sleep to wakefulness within 10 s of the start of stimulation (Stim+ atr, n = 6; Stim day + atr and mec, n = 4). *p < 0.05 (one-way repeated-measures ANOVA post hoc Holm–Sidak). Data are mean ± SEM.