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. 2016 Feb 8;7:10656. doi: 10.1038/ncomms10656

Figure 3. Involvement of LPARs in LPA-induced invasion and Arf6 activation of 786-O cells.

Figure 3

(a,b) Ki16425 inhibits LPA-induced Matrigel invasion activity (a) and Arf6 activation (b). Ki16425 was applied to the cells at the indicated concentrations, 3 h before the experiments and was present during the experiments. (c,d) Involvement of endogenous LPAR1-3 in LPA-induced Matrigel invasion (c) and Arf6 activation (d), as assessed by their gene silencing using specific siRNAs, as indicated. In c and d, siRNA with an irrelevant sequence (Irr) was included as a control. (a,c) Error bars show the mean±s.e.m., n=3. *P<0.05, **P<0.01. Statistical analyses were performed using analysis of variance.