Mice were subjected to HI at P9 or P30 with and without minocycline treatment and Morris water maze MWM testing was performed at 60 days post-HI. A. Summary figure of time to platform over the four days of training in sham, HI and HI + minocycline-treated P9 mice. Data are mean ± sem. n = 5-9 * p < 0.05 vs Day 1 value. B. Summary figure of time to platform over the four days of training in sham, HI and HI + minocycline-treated P30 mice. Data are mean ± sem. n = 11-12. * p < 0.05 vs Day 1 value. C. Summary of platform crossings for each quadrant in P9 sham, HI and HI + minocycline-treated mice. Q1 = Training Quadrant; *p<0.05, n=5-9. D. Summary of platform crossings for each quadrant in P30 sham, HI and HI + minocycline-treated mice. Q1 = Training Quadrant; *p<0.05, n=11-12.