Table 3. Diagnostic accuracy of MTBDRplus and MTBDRsl for the direct detection of drug resistance in sputum samples according to HIV status compared to phenotypic culture-based susceptibility testing (reference standard).
| All sputum samples |
Smear-positive sputum |
Smear-negative sputum |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HIV-infected |
HIV-uninfected |
HIV-infected |
HIV-uninfected |
HIV-infected |
HIV-uninfected |
||||||||
| Sensitivity(%) | Specificity(%) | Sensitivity(%) | Specificity(%) | Sensitivity(%) | Specificity(%) | Sensitivity(%) | Specificity(%) | Sensitivity(%) | Specificity(%) | Sensitivity(%) | Specificity(%) | ||
| MTBDRplus(v 1.0) | RIFR | 96.7 (29/30) | 90 (9/10) | 98 (49/50) (p = 0.712) | 88.2 (15/17) (p = 0.888) | 100 (23/23) | 100 (8/8) | 97.7 (43/44) (p = 0.466) | 100 (14/14) | 100 (7/7) | 100 (1/1) | 100 (8/8) | 100 (1/1) |
| INHR | 93.3 (28/30) | 90 (9/10) | 96 (48/50) (p = 0.596) | 88.2 (15/17) (p = 0.888) | 91.6 (22/24) | 100 (8/8) | 97.6 (41/42) (p = 0.264) | 50 (2/4) | 100 (7/7) | 100 (1/1) | 87.5 (7/8) (p = 0.333) | 100 (1/1) | |
| MTBDRsl(v 1.0) | OFXR | 48.1 (13/27) | 94.4 (17/18) | 64.1 (25/39) (p = 0.197) | 83.3 (25/30) (p = 0.260) | 69 (11/16) | 100 (9/9) | 82.1 (23/28) (p = 0.308) | 100 (17/17) | 18.2 (2/11) | 100 (2/2) | 18.2 (2/11) | 100 (1/1) |
| AMKR | 59.2 (16/27) | 100 (18/18) | 64.1 (25/39) (p = 0.690) | 90 (27/30) (p = 0.166) | 62.5 (10/16) | 100 (9/9) | 78.6 (22/28) (p = 0.250) | 100 (17/17) | 50 (6/12) | 100 (2/2) | 27.3 (3/11) (p = 0.265) | 100 (1/1) | |
P-values are for comparisons between HIV statuses.
RIFR = rifampicin resistance, INHR = isoniazid resistance, OFXR = ofloxacin resistance, AMKR = amikacin resistance.