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. 2015 Jul 23;156(10):2072–2083. doi: 10.1097/j.pain.0000000000000273

Figure 1.

Figure 1

Association analysis results and genomic localization of SNP rs165774 (G>A, minor allele frequency: 0.315). (A) Forest plot depicting odds ratios (OR; with 95% confidence intervals) for COMT SNP rs165774 and risk of TMD; (B) Forest plot depicting regression coefficient (β; with 95% confidence intervals) for COMT SNP rs165774 and pressure pain. The analysis was performed in TMD case–control and OPPERA cohorts; CI, 95% confidence interval; L95, lower bound of 95% confidence interval; Meta, meta-analysis; OR, odds ratio; U95, upper bound of 95% confidence interval; β, regression coefficient. (C) Alternative (a)MB-COMT transcript (CR616943 and BX449536.2) shares its 5′ sequence with MB-COMT—one of the 2 reference COMT transcripts. At base pair (bp) position 865, transcription leaks through intron 5 until polyadenylation site, creating an alternative splice variant. Red star: alternatively spliced COMT transcript; purple star: reference MB-COMT isoform; green star: reference S-COMT isoform.