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. 2016 Feb 9;13:35. doi: 10.1186/s12974-016-0489-7

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© Tao et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — The mRNA and protein expressions of pro-inflammatory cytokines in DIZE pre-treated hRPE and ARPE-19 cells followed by LPS stimulation. Real-time PCR and ELISA were conducted to determine the production of IL-6, IL-8, and MCP-1 in ARPE-19 cells (a) as well as hRPE (b). Exposure to LPS for 24 h caused a significant overproduction of IL-6, IL-8, and MCP-1 in the ARPE-19 cells and hRPE. Whereas overproduction of the cytokines was markedly inhibited by DIZE. IL-6 and IL-8 protein levels were undetectable in the DIZE group. All data are expressed as mean ± SEM. (***p < 0.001, **p < 0.01, *p < 0.05, n = 4)