Table 2.
Over-represented Gene Ontology Biological Process (GOBP) terms that can be found in various intestinal sections
| Section and Responses | GO ID | GOBP | Proximal | Middle | Distal | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Set Size | Hits | Adjusted p-value | Set Size | Hits | Adjusted p-value | Set Size | Hits | Adjusted p-value | |||
| Prox-Mid-Dist (all linear) | GO:0006953 | Acute-phase response | 22 | 5 | 0.09 | 22 | 6 | 0.08 | 21 | 3 | 0.03 |
| Prox-Mid (lm - lm) | GO:0006629 | Lipid metabolic process | 184 | 33 | <0.01 | 183 | 46 | <0.01 | |||
| GO:0006631 | Fatty acid metabolic process | 68 | 19 | <0.01 | 67 | 28 | <0.01 | ||||
| GO:0006635 | Fatty acid beta-oxidation | 21 | 9 | <0.01 | 21 | 11 | <0.01 | ||||
| GO:0006637 | Acyl-CoA metabolic process | 19 | 7 | <0.01 | 19 | 6 | 0.04 | ||||
| GO:0007040 | Lysosome organization | 18 | 5 | 0.03 | 18 | 6 | 0.04 | ||||
| GO:0015031 | Protein transport | 386 | 45 | 0.01 | 387 | 60 | <0.01 | ||||
| GO:0022900 | Electron transport chain | 69 | 14 | <0.01 | 69 | 18 | <0.01 | ||||
| GO:0055085 | Transmembrane transport | 390 | 42 | 0.07 | 391 | 57 | 0.02 | ||||
| Prox-Mid (lm - log) | GO:0042632 | Cholesterol homeostasis | 33 | 11 | <0.01 | 33 | 4 | 0.10 | |||
| Prox-Mid (lm - exp) | GO:0030301 | Cholesterol transport | 15 | 7 | <0.01 | 15 | 4 | 0.03 | |||
| Mid-Dist (lm - lm) | GO:0006520 | Cellular amino acid metabolic process | 16 | 5 | 0.07 | 16 | 2 | 0.05 | |||
| GO:0016042 | Lipid catabolic process | 69 | 14 | 0.05 | 69 | 5 | 0.03 | ||||
| GO:0051262 | Protein tetramerization | 17 | 5 | 0.09 | 17 | 2 | 0.05 | ||||
| Mid-Dist (lm - exp) | GO:0043154 | Negative regulation of caspase activity | 36 | 10 | 0.02 | 36 | 2 | 0.06 | |||
| Mid-Dist (log - lm) | GO:0006644 | Phospholipid metabolic process | 17 | 4 | 0.01 | 17 | 2 | 0.05 | |||
| GO:0006749 | Glutathione metabolic process | 24 | 4 | 0.04 | 24 | 2 | 0.08 | ||||
| GO:0045859 | Regulation of protein kinase activity | 16 | 4 | 0.01 | 16 | 2 | 0.05 | ||||
We summarize total number of genes corresponding to a given GO term in the microarray gene expression (gene set size, labelled as Set Size), count of genes extracted with our analysis (observed hits, labelled as Hits) and adjusted p-values (values have been rounded-up to two decimal points; adjusted p-value < 0.1). Intestine sections: Prox = proximal; Mid = middle; Dist = distal. Response types: lm = linear; log logarithm; exp = exponential. GOBP terms showing quadratic and cubic response types have been excluded as they can be found in the middle section only (i.e., there are no spatial trends along the small intestine axis; see Table 1)