Table 3.
Diagnostic accuracy for SLE of the PNC assay, CLIFT, and their combined positivity in MRG patients
| PNC+ | CLIFT+ | PNC+CLIFT+ | |
|---|---|---|---|
| Sensitivity (95 % CI) | 0.20 (0.12–0.37) | 0.32 (0.22–0.44) | 0.15 (0.09–0.26) |
| Specificity (95 % CI) | 0.95 (0.93–0.97) | 0.95 (0.93–0.97) | 0.99 (0.97–0.99) |
| PPV (95 % CI) | 0.37 (0.23–0.54) | 0.48 (0.34–0.62) | 0.67 (0.42–0.85) |
| LR+ (95 % CI) | 4.22 (2.24–7.96) | 6.52 (3.83–11.10) | 14.28 (5.04–40.46) |
| LR− (95 % CI) | 0.84 (0.74–0.95) | 0.71 (0.60–0.84) | 0.86 (0.77–0.95) |
CI confidence interval, PPV positive predictive value, LR+ likelihood ratio for positive result, LR− likelihood ratio for negative result, CLIFT Crithidia luciliae immunofluorescence test, PNC phagocytosis of necrotic cell material, MRG multicenter rheumatic group, SLE systemic lupus erythematosus