Table 4. Genes (n=49) with differential methylation associated with at least one EUC arsenic species and their relationship to metabolic disease and cancer.
An “x” indicates a relationship of a gene to metabolic disease and/or cancer signaling. Genes are also specified as being hyper- or hypomethylated in bladder cancer tissue.
| Gene Symbol(s) |
Gene Name | Associated EUC Arsenical(s) |
Metabolic Disease Signaling (p=0.001) |
Cancer Signaling (p=0.002) |
Gene Promoter Hyper- / Hypomethylation in Bladder Cancer |
|---|---|---|---|---|---|
|
AK095619 / DLX6-AS1 |
DLX6 antisense RNA 1 | tAsV, tAsIII+V | |||
|
AK097754 / RGPD4-AS1 |
RGPD4 antisense RNA 1 (head to head) |
tAsIII+V, iAsIII+V, MMAsIII, MMAsIII+V |
|||
| ANKFY1 | Ankyrin repeat and FYVE omain containing 1 |
tAsIII+V | x | Hypomethylation | |
| ANPEP | Alanyl (membrane) aminopeptidase |
tAsIII+V, iAsIII+V, MMAsIII, MMAsIII+V |
x | Hypermethylation | |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 |
tAsV, tAsIII+V | x | Hypomethylation | |
| ASTN2 | Astrotactin 2 | tAsIII+V | x | ||
| ATP5D | ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit |
tAsIII+V | Hypermethylation | ||
|
AX748071 / RIIAD1 |
Regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 |
tAsIII+V | |||
|
BC041459 / TARID |
TCF21 antisense RNA inducing promoter demethylation |
tAsIII+V | |||
|
C10orf139 / LINC00200 |
Long intergenic non-protein coding RNA 200 |
tAsIII+V | |||
|
C5orf39 / ANXA2R |
Annexin A2 receptor | tAsV, tAsIII+V | Hypomethylation | ||
| CALHM1 | Calcium homeostasis modulator 1 |
tAsIII+V | x | Hypermethylation | |
| COL12A1 | Collagen, type XII, alpha 1 | tAsIII+V | x | ||
|
CR605298 / FENDRR |
FOXF1 adjacent non-coding developmental regulatory RNA |
tAsIII+V | |||
| EOMES | Eomesodermin | tAsIII+V, MMAsIII+V |
x | Hypomethylation | |
| FBXW8 | F-box and WD repeat domain containing 8 |
tAsIII+V | Hypomethylation | ||
| GGA2 | Golgi-associated, gamma adaptin ear containing, ARF binding protein 2 |
tAsV | x | ||
| GPNMB | Glycoprotein (transmembrane) nmb |
tAsV, tAsIII+V | x | x | |
| HIST1H3G | Histone cluster 1, H3g | tAsIII+V, MMAsIII+V |
|||
| IGFBP5 | Insulin-like growth factor binding protein 5 |
tAsV, tAsIII+V | x | x | Hypermethylation |
| IGSF21 | Immunoglobin superfamily, member 21 |
tAsIII+V | Hypermethylation | ||
|
IQWD1 / DCAF6 |
DDB1 and CUL4 associated factor 6 |
tAsV | |||
| KCNT2 | Potassium channel, subfamily T, member 2 |
tAsIII+V | x | ||
| LAMA2 | Laminin, alpha 2 | tAsIII+V, iAsIII+V, MMAsIII+V |
x | Hypermethylation | |
| LRP5L | Low density lipoprotein receptor-related protein 5-like |
tAsIII+V | |||
| LRRC40 | Leucine rich repeat containing 40 |
MMAsIII+V | x | ||
| MAFF | V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F |
tAsIII+V | |||
| MAPK15 | Mitogen-activated protein kinase 15 |
tAsV, tAsIII+V, iAsV | Hypermethylation | ||
| MEIS2 | Meis homeobox 2 | tAsV, tAsIII+V, iAsIII+V |
x | ||
| METTL13 | Methyltransferase like 13 | tAsV, tAsIII+V, iAsV, iAsIII+V, MMAsIII, MMAsIII+V |
|||
| NCAN | Neurocan | tAsIII+V | x | Hypermethylation | |
| NRSN1 | Neurensin 1 | tAsIII+V | x | Hypermethylation | |
| OR4Q3 | Olfactory receptor, family 4, subfamily Q, member 3 |
tAsIII+V | x | ||
| OR8S1 | Olfactory receptor, family 8, subfamily S, member 1 |
tAsV | Hypermethylation | ||
| PCDHGC5 | Protocadherin gamma subfamily C, 5 |
tAsV, tAsIII+V, iAsV, iAsIII+V, MMAsIII, MMAsIII+V |
x | ||
| PRDM2 | PR domain containing 2, with ZNF domain |
tAsIII+V | x | Hypermethylation | |
|
PRIC285 / HELZ2 |
Helicase with zinc finger 2, transcriptional coactivator |
tAsIII+V | |||
| PSMB2 | Proteasome (prosome, macropain) subunit, beta type, 2 |
tAsIII+V | x | x | Hypermethylation |
| RALGPS1 | Ral GEF with PH domain and SH3 binding motif 1 |
tAsIII+V | x | Hypermethylation | |
| SLC12A7 | Solute carrier family 12 (potassium/chloride transporter), member 7 |
tAsV, tAsIII+V, MMAsIII+V |
x | x | Hypomethylation |
| TAOK2 | TAO kinase 2 | tAsIII+V | |||
| TMSB15A | Thymosin beta 15a | tAsIII+V, iAsIII+V | |||
| TRAF3IP1 | TNF receptor-associated factor 3 interacting protein 1 |
tAsIII+V | x | ||
| UBE3C | Ubiquitin protein ligase E3C | tAsIII+V | x | ||
| USP7 | Ubiquitin specific peptidase 7 | tAsIII+V, MMAsIII+V |
x | x | Hypermethylation |
| VWA3A | Von Willebrand factor A domain containing 3A |
MMAsIII+V | Hypermethylation | ||
| YJEFN3 | YjeF N-terminal domain containing 3 |
tAsIII+V | Hypomethylation | ||
| ZBTB39 | Zinc finger and BTB domain containing 39 |
tAsIII+V | x | ||
| ZNF14 | Zinc finger protein 14 | tAsV, iAsIII+V | x |