. Author manuscript; available in PMC: 2016 Feb 10.

Published in final edited form as: Nat Rev Gastroenterol Hepatol. 2010 Jul 27;7(9):503–514. doi: 10.1038/nrgastro.2010.117

Table 2.

Effects of probiotics in randomized, clinical trials of intestinal disease

Disease	Effect
Crohn’s disease	Little or no benefit⁵⁰
Ulcerative colitis	Increased maintenance of remission in children^76,77
IBS	Better quality trials required to confirm benefit on clinical symptoms (abdominal pain, bloating, stool consistency)^33,34
Clostridium difficile infection	May prevent infection and recurrence of infection⁹⁵
Infectious diarrhea	Decreases the severity and duration of diarrhea^103–105
Antibiotic-associated diarrhea	Prevention of diarrhea¹⁰¹ and reduction of symptoms¹⁰⁰
Necrotizing enterocolitis	Reduces mortality⁸⁴