Table 1.

Adverse events on treatment with second-line drugs (N=823)

Adverse event	Number (percent*)
Nausea	540 (65.6)
Diarrhea	249 (30.3)
Ototoxicity (hearing disturbances)	130 (15.8)
Headache	95/602** (11.5)
Hypokalemia	99/221** (14.9)
Peripheral neuropathy	76 (9.2)
Hypothyroidism	40 (4.9)
Seizure	39 (4.7)
Psychosis	35/379** (4.3)
Hepatitis	19 (2.3)
Renal insufficiency (elevated creatinine)	15/602** (1.8)

^*Percentage from total 823 unless states otherwise.

^**Denominator is number of patients with available data on particular adverse event.