. Author manuscript; available in PMC: 2016 Dec 10.

Published in final edited form as: J Control Release. 2015 Aug 6;219:237–247. doi: 10.1016/j.jconrel.2015.08.011

Table 2.

Different mechanisms of current SMIRs

Stage	SMIRs	Mechanism	Reference
Pre-transcription	LAQ824	Inhibiting histone deacetylases	¹³⁶
Transcription	JQ1	Inhibiting c-Myc	^137–139
Post-transcription	Streptomycin, xanthone derivatives, AC1MMYR2, poly-L-lysine hydrobromide, 3,6-diamino-10-methylacridinium chloride, aurintricarboxylic acid, Enoxacin	Binding pre-miRNA or pri-miRNA; binding Dicer, Drosha, or AGO2; inhibiting Dicer process or RISC loading, enhancing TAR RNA-binding protein 2-mediated miRNA processing	^{110,115,120,122,123,132,141–143}