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. 2016 Feb 10;11(2):e0149131. doi: 10.1371/journal.pone.0149131

Fig 2. Synthesis of the Hydroxy Pyrazolines as CFTR potentiators.

Fig 2

(i) KOH, EtOH, stir; (ii) Chloro(methoxy)methane (MOMCl), K2CO3, Acetone, reflux; (iii) substituted benzaldehydes 2a-2c, KOH, EtOH, stir; (iv) 3N HCl, reflux; (v) 4-hydrazinobenzenesulfonamide hydrochloride (see Materials and Methods).