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. 2016 Feb 10;11(2):e0148323. doi: 10.1371/journal.pone.0148323

Fig 6. VEGF sequestration decreases PI3K-Akt and MAPK-ERK pathway signaling.

Fig 6

Western blot data for (A) PI3K, (B) phosphorylated and total Akt, and (C) phosphorylated and total ERK1/2 demonstrate decreased activation of these signaling pathways in mutants. (D) Western blot data also show decreased relative production of HIF-1α in mutant mice. (E) Mutant mice also express decreased relative levels of activated EGFR, which could further decrease surfactant production through its synergistic effect on VEGF expression. Data are expressed as mean ± SD, *P<0.05 vs control.