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| Study purpose | Setup-1 Single hepatocyte | Setup-2 Double hepatocyte | Setup-3 LSEC-double hepatocyte | Setup-4 LSEC-hepatocyte |
|---|---|---|---|---|
| 3D migration through ECM | √ | √ | √ | √ |
| Directional migration to hepatocytes | √ | √ | √ | √ |
| Crossing hepatocyte layers | — | √ | √ | — |
| Crossing endothelial barrier | — | — | √ | √ |
| LSEC response to the presence of pathogens | — | — | √ | √ |
