Table 1. Average MM/PBSA free energies of MDM2-polyphenol complexes calculated from the MD simulations performed in triplicate.

Ligands	Van der waal (kJ/mol)	Electrostattic (kJ/mol)	Polar salvation (kJ/mol)	Non-polar salvation (kJ/mol)	Binding energy (kJ/mol)
Apigenin	-149.81±11.91	-23.65±1.41	47.08±10.91	-14.22±0.76	-139.48±3.53
Fisetin	-154.62±1.20	-36.39±13.53	32.29±0.23	-13.74±0.50	-172.25±13.70
Galangin	-152.04±13.27	-12.98±5.90	36.54±4.60	-13.01±0.93	-142.48±1.40
Luteolin	-170.40±20.29	-12.42±9.10	23.84±0.97	-14.82±0.028	-173.80±4.34