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. 2016 Feb 10;11(2):e0148266. doi: 10.1371/journal.pone.0148266

Fig 11. Alternative mRNA splicing and selected single nucleotide polymorphisms for GJC3 products.

Fig 11

CCDS entry CCDS34697.1 (accessed 24 May 2012) for transcribed mRNA from GJC3 (NM_181538.2 and NP_853516.1) and its translated 279 amino acid polypeptide showing the alternate exon region, designated with a blue rectangle. Residues highlighted in purple (M1V, R4V, P19H, R22H, E268D) indicate single nucleotide polymorphisms (SNPs: see main text) leading to variation in coded amino acids within predicted geometrically neighbouring and functionally significant N- and C-terminal regions. V261 highlighted in orange indicates the C-terminal splice variant start point. Discovered residues correspond to amino acids 1–25. Underlined residues S227S, T234N highlighted in green indicate phosphorylation sites identified from PhosphositePlus and genomic SNPs.