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. 2016 Feb 10;11(2):e0149068. doi: 10.1371/journal.pone.0149068

Fig 1. Visual deprivation-induced enhancement of AMPA receptor-mediated currents at layer4-2/3 synapses of the juvenile barrel cortex lasts for a week.

Fig 1

(A) Schematic representation of electrophysiological experiment. Excitatory synaptic responses of layer 4-2/3 synapses were recorded in this experiment. (B) (Left) Synaptic responses at layer 4-2/3 synapses in the barrel cortex of intact rats (Intact) or rats with 7days visual deprivation (7days VD). (Right) Mean ratio of AMPAR-mediated currents to NMDA receptor-mediated currents (A/N ratio). Note no difference of A/N ratio between Intact and 7days VD. (Intact: n = 9, 7days VD: n = 10). (C) Responses (spike frequency) in layer 2/3 neurons to deflection of first-order surrounding (S1) whiskers normalized to the response for the principal whisker. 7days VD showed lower values in S1 than Intact, indicating that the whisker-barrel map was remained sharpened in 7days VD rats (Intact: n = 10, 7days VD: n = 8. *, p < 0.05, Student's t-test. Error bars, ±SEM).