Fig 4. Incidence of invasive pneumococcal disease among persons 5 years and older by the commonest 15 serotypes causing disease, South Africa, 2003–2008 (n = 17 604).

Footnote: * Significant changes during the established surveillance period (2005–2008) were seen in serotype 1 (p<0.001) (down), 4 (0.02) (up), 6A (p = 0.0486) (down), 19F (p = 0.0306) (down), 12F (p = 0.0037) (down), 18C (p = 0.0368) (up). Of 17 604 cases of IPD, serotype data were missing and thus imputed for 5 041 cases.