Table 1. The five measured perfusion parameters in the RT-alone and AART groups.
Parameter | RT (n = 5) | AART (n = 4) | P-value |
---|---|---|---|
Kep | 0.0002 (0.0001, 0.0049) | 0.00006 (0.00003, 0.00012) | 0.190 |
Kel | 0.0062 (0.0032, 0.0214) | 0.0490 (0.0202, 0.0753) | 0.063 |
Splat/TTP | 0.0049 (0.0035, 0.0061) | 0.0107 (0.0078, 0.0142) | 0.016 |
AH | 9.40 (1.85, 162.3) | 794.05 (201.13, 1958.61) | 0.063 |
MER | 1.49 (1.354, 1.6126) | 1.81 (1.7488, 1.8925) | 0.016 |
The data are medians with the interquartile ranges in parentheses. RT, radiation therapy; AART, SU11248 plus RT; Kep (sec -1), exchange rate constant from the extracellular space back to the plasma in the vascular structure; Kel (sec -1), elimination rate constant from the plasma to the renal excretion; Splat, signal intensity in the plateau; TTP, time to peak enhancement; AH, constant corresponding to the size of the interstitial space; and MER, maximum enhancement ratio.