Fig 5. anticonvulsive compounds reduce I_NaP.

A) I_NaP is increased in bss¹ relative to wildtype (WT). I_NaP was evoked using a voltage protocol that maintained the aCC neuronal membrane at 0mV to inactivate I_NaT before dropping to -30mV to measure maximal I_NaP. Treatment with rapamycin reduces I_NaP back to WT level. The three recordings shown were chosen because they have the same amplitude of I_NaT. The dotted lines are drawn as indictors only to show amplitudes of I_NaT and I_NaP in WT. B) Ratio for I_NaP/NaT recorded in aCC for bss¹ raised in food containing either rapamycin, dipyramidole, isethionate, antipain or etopiside (concentrations as per Table 1). Values for untreated bss¹ and WT are shown for reference. C) Ratio for I_NaP/NaT for bss¹ following expression of RNAi transgenes targeting raptor, phosphodiesterase 11 (PDE11), CDK4, serine-type peptidase (SP) or topoisomerase II (TopII). Values are means ± sem.